Urticaria is also known as hives. The condition is characterized by an outbreak of swollen, pale red bumps on the skin. It usually occurs suddenly; it results from either body reaction to specific allergens. An allergen refers to something which produces an allergic reaction to the body.
In most cases, the allergic reaction in human bodies, when an allergic reaction occurs, it releases histamine which accumulates in the blood vessels known as leak fluid. This then causes a rash on the human body.
Cellular mechanism of urticaria
The skin lesions which are caused by the hives are usually raised red and itchy bumps. In most cases, the reaction begins itchy cutaneous mast cells and the basophils releasing the histamine and many other inflammatory mediators on the skin surface. When the response occurs, the mast cells are stimulated to release the chemicals known as Immunoglobulin E, which binds to any of the allergens to fight against any foreign component in the body. In addition, the histamine triggers the dilation of the blood vessels causing the skin to become reddish. This type of dilation later becomes leaky and releases the fluids which cause swelling of the skin or edema of the skin. Therefore, making the skin to remain to release excess fluids by the surrounding cells thus swelling (Maurer, et al., 2017).